For decades the Guardians and Caretakers of the Genome research team at the Erasmus MC in Rotterdam has been focusing on how exactly cells do in fact repair themselves. What is unique about this team is that they study this process, in relation to ageing and cancer, at difference levels of complexity: In relation to cancer and ageing, for example, they are looking atfrom single individual molecules to as well as at complete physiological processes within the cell or the patient.